Platelet Rich Plasma (PRP) and Platelet Rich Fibrin (PRF) simulates tissue regeneration and can be usefull in treating osteonecrosis bisphosphonate induced.

Material and methods : Between January 2012 and January 2013, in 21 patients, PRP was used alone (11 cases), in association with PRF (8 cases) or with fat by lipostructure (3 cases). 6 of the patients presented osteonecrosis induced by bisphosphonates used to treat bone metastasis, in 4 cases PRP was used to treat mandibular osteoradionecrosis, and in 7 patients it was used for the treatment of atonic wounds from multipleoperated iradiated regions (in 4 cases alone and in another 3 combined with fat, by lipostructure). In 5 patients treated with bisphosphonates for bone metastasis, after tooth extractions, prophylactic, PRP and PRF was used.

Results : The number of patients included in the study was small but the good results recommend the technique. The healing of the bone necrosis was in 3–6 weeks and the atonic wounds was healed in maximum 4 weeks. In the prophylactic patients, jaw necrosis did not appear during the follow-up period.

Conclusions : The PRP alone or combined with PRF or fat, is a technique that is less traumatic, with fast and high quality effects.