Background and objectives: rhBMP-2 has been used in maxillofacial reconstruction since 2007 and appears to be one the most promising biomaterial. The main advantage was the shortening operation time, absence of donor site morbidity and shorter hospital stay. This study report the off-label use of rhBMP-2 for the management of non-union complications after orthognathic surgery.

Materials and methods: A case review was made of 3 patients who developed non-union of the jaws after Le Fort I and sagittal osteotomies. Two patients had non-union of the mandible and one patient had non-union of the maxilla. The rhBMP-2 with a collagen carrier was used with and without the association of autogenous bone to graft the non-union site.

Results: All of the cases reported had successful osseous restoration of the non-union site. Bone formation could be seen at the end of 90 days by clinical and radiograph assessments. The patients progress with stability of the jaws and occlusal functions restored.

Conclusion: This study indicated that the rhBMP-2 played an important role in the reconstruction of the non-union surgical sites after orthognathic surgery and can be an alternative method of treatment that reduce surgical morbidity.

Key words: non-union; rhBMP-2; orthognathic surgery