Objective : This clinical and radiographic prospective study investigated the effect of Platelet Rich Plasma (PRP) on iliac crest graft as a method of mandibular reconstruction.

Patients and methods : This was a prospective comparative study carried out on 17 patients. Nine of them were submitted to mandibular reconstruction by iliac crest graft with Platelet Rich Plasma (PRP) and the remaining eight patients underwent mandibular reconstruction by iliac crest graft without Platelet Rich Plasma (PRP). This was carried out at Plastic Surgery Unit in the Department of Surgery, Suez Canal University Hospital along the period of two years (from October 2009 to October 2011). Patients were assessed clinically and using dental CT.

Results : There was no effect of Platelet Rich Plasma (PRP) on the final outcome of the bone density of the grafted area at the end of follow up, and the only effect of PRP was detected at the early stage of the graft osteogenesis.

Conclusion : The effect of PRP was restricted to decrease pain level and accelerate the healing response post-operatively. The extent of the mandibular defect represented the only significant factor associated with the occurrence of postoperative complications.