Alveolar bone repair process in spontaneously hypertensive rats untreated and treated with losartan. Histomorphometric and immunohistochemical analysis

Background and objectives: Hypertension is a multifactorial clinical condition, with high rates of complications, considered one of the greatest public health problems worldwide. Hypertension alters calcium regulation pattern provoking bone loss. The aim of this research was to evaluate alveolar bone repair process in spontaneously hypertensive (SHR) and Wistar rats treated with losartan (30 mg/kg/day).

Methods: A total of 60 rats were divided into 4 groups: (A) Wistar; (B) SHR; (C) Wistar treated; (D) SHR treated. Upper right dental incisors were extracted, after 7, 14, and 28 days post-operative animals were euthanized. Biological mechanisms of alveolar bone repair were histomorphometry and immunohistochemistry analyzed by OPG protein, RANKL, TRAP and PECAM expression involved in bone metabolism. Data were statistically analyzed by Kruskal–Wallis non-parametric test.

Results: The SHR group showed alveolar bone repair delay. Losartan use improved bone repair process in Wistar and SHR, resulting in increased bone formation, as well as greater trabecular thickness. The proteins tagged, participate actively in bone dynamic, it was observed losartan direct action during bone repair.

Conclusion: It is suggested that losartan and the renin–angiotensin interfere with bone metabolism through the action of angiotensin II.

Key words: hypertension; SHR; losartan; bone repair; immunohistochemistry

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Jan 21, 2018 | Posted by in Oral and Maxillofacial Surgery | Comments Off on Alveolar bone repair process in spontaneously hypertensive rats untreated and treated with losartan. Histomorphometric and immunohistochemical analysis
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