Sclerotherapy is an alternative for the treatment of oral vascular lesions; Polidocanol is one of the most commonly used sclerosing agents. Despite being used for decades in the literature there is no established protocol for its use or comparative results have not been published.

Objective: To compare the effectiveness of different concentrations of the Polidocanol in the treatment of oral vascular malformations.

Materials and methods: 33 oral vascular lesions were sclerosed. These lesions were divided into 2 groups, group 1 included lesions size to 0.5 cm and group 2, lesion of 0.6–2 cm. Polidocanol was used in a weekly base on a dose of 0.1 ml at 0.5% and 1% in each group. 17 lesions were included in the treatment group 1 and 16 in group 2. During treatment were assessed pre-established clinical parameters.

Results: The average number of sessions required to achieve remission of the lesions of the group 1 infiltrate at 0.5 were 4 ± 1.2, for group 1 treated at 1% was 3.38 ± 1.06, for group 2 lesions treated at 0.5%, the average of 5.63 ± 0.92, those treated at 1% will present an average of 5.63 with a +1.30 DS.

Conclusion: Polidocanol at these doses and concentrations is effective in the treatment of oral vascular lesions. Lesions of group 1 do not present significant differences between concentrations and the lesions of group 2 had the same mean, allowing us to recommend the lowest concentration in the treatment of these lesions

Conflict of interest: Sclerotherapy is an alternative for the treatment of oral vascular lesions. One of the most used is the Polidocanol. Despite being used for decades in the literature there is no established protocol for its use or comparative results have not been published.