Introduction/aims: In 1986 Wain et al. coined the term Basaloid Squamous Cell Carcinoma (BSCC) and it is only since then that this condition has been recognised as a separate entity. BSCC is an aggressive variant of squamous cell carcinoma with basaloid components in varying proportions. Only 200 cases have been reported in literature so far. In this presentation, we shall examine our cancer network’s experience with this disease. There is an emerging link with Human Papilloma Virus also.

Material/methods: A retrospective case-series of patients diagnosed histologically with oral basaloid squamous cell carcinoma between 2004 and 2009 at Northwick Park hospital were assessed. Clinical data was collected from case notes.

Results: 7 patients were found to have this variant of disease. The presenting complaints of all the patients were late and vague and this added to the difficulty in diagnosis. However all the cases were at an advanced stage with extensive lymph node metastases at initial presentation.

Conclusion/relevance: The condition was found to be aggressive and occurred in younger patients on average.

Surgery followed by chemo-radiotherapy was the treatment of choice.

Our management and findings will be presented.

Conflict of interest: None declared.