A case of carcinoma of maxillary sinus treated by multidisciplinary therapy

Squamous cell carcinoma of maxillary sinus is difficult for treatment from the influence to the internal organ that adjoins. We report a case of squamous cell carcinoma of maxillary sinus of local advanced treated by multidisciplinary therapy.

A 61-years-old woman visited us with stage IV disease of squamous cell carcinoma of maxillary sinus. PET-CT showed abnormality accumulation (SUV 48.02) of left maxillary sinus and no other abnormal accumulation.

She was treated by three cycles of docetaxel (DTX) 75 mg/m 2 /day, cisplatin (CDDP) 100 mg/m 2 /day, and 5-flurouracil (5-FU) 1000 mg/m 2 /day (TPF) induction chemotherapy and then en-block resection. Induction TPF consisted of DTX 75 mg/m 2 (3-h i.v. infusion day 1) followed by CDDP 100 mg/m 2 (2-h i.v. infusion day 1) and 5-FU 1000 mg/m 2 (96 h continuous i.v. infusion, starting after the CDDP infusion). Cycles were repeated every 3 weeks.

Chemoradiotherapy Weekly carboplatin 150 mg/body + 66 Gy was performed after the surgery because the tumor was recognized to the resection edge from pathological report. There has been no evidence of recurrence and metastasis as 3 years after surgery.

Conflict of interest: None declared.

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Feb 5, 2018 | Posted by in Oral and Maxillofacial Surgery | Comments Off on A case of carcinoma of maxillary sinus treated by multidisciplinary therapy
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