! The serious reactions of long-term therapy and the addition of occlusive dressings are reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria.
! Overdosage can occur from topically applied halobetasol absorbed in sufficient amounts to produce systemic effects producing reversible adrenal suppression, manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria in some patients.
An antipsychotic, antiemetic, and antidyskinetic agent that competitively blocks postsynaptic dopamine receptors, interrupts nerve impulse movement, and increases turnover of dopamine in the brain. Has strong extrapyramidal and antiemetic effects; weak anticholinergic and sedative effects.
Readily absorbed from the GI tract. Protein binding: 92%. Extensively metabolized in the liver. Primarily excreted in urine. Not removed by hemodialysis. Half-life: 12–37 hr PO; 10–19 hr IV; 17–25 hr IM.
! Tardive dyskinesia (tongue protrusion, puffing of the cheeks, chewing or puckering of the mouth) may occur during long-term therapy or after discontinuing the drug and may be irreversible. Elderly female patients have a greater risk of developing this reaction.
• Physician should be informed if significant xerostomic side effects occur (e.g., increased caries, sore tongue, problems eating or swallowing, difficulty wearing prosthesis) so that a medication change can be considered.
Inhibits gonadotropin secretion. It increases level of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) upon initiation of treatment but after continuous administration will decrease LH, FSH, testosterone, and estrogen.
Contraindicated in patients with a history of hypersensitivity to GnRH, GnRH agonist analogs, histrelin acetate, or any component of the product; pregnancy (may cause fetal harm and spontaneous abortion).
Well absorbed from the GI tract. Widely distributed. Protein binding: 85%–90%. Metabolized in the liver to active metabolite. Primarily excreted in urine. Not removed by hemodialysis. Half-life: 3–7 hr (increased with impaired renal function).
A sulfonamide derivative that acts as a thiazide diuretic and antihypertensive. As a diuretic, blocks reabsorption of water, sodium, and potassium at the cortical diluting segment of the distal tubule. As an antihypertensive reduces plasma, extracellular fluid volume, and peripheral vascular resistance by direct effect on blood vessels.