Squamous cell carcinoma is one of the most common malignancies in head and neck region. Primary tumors, especially derived from undifferentiated cells, tend to have an aggressive phenotype, mainly characterized…
Background and objective: We have reported reciprocal switching in the keratin (K) subtype expression from K13 to K17 occurs during malignant transformation of the oral mucosa from normal and dysplastic…
Introduction: Squamous cell carcinoma of the oral cavity usually affects patients between the fifth and seventh decade of life but is increasingly seen in young patients under 40 years. Material…
The authors present the clinical case of a malignant paraganglioma of the parapharyngeal region: diagnosis, surgery and treatment with radiotherapy, MIBG-I131, chemotherapy and octreotid. 63 year old woman was referred…
Background and objectives: Fatty acid binding protein 4 (FABP4) is an intracellular lipid chaperone molecules that are expressed and involved in functions of adipocyte, macrophage, and dendritic cell. However, little…
Background and objectives: The aim of this study is to examine the effect of Image-guided stereotactic radiotherapy (IGSRT) in the treatment of advanced, recurrent lesions for head and neck carcinoma…
Tumor hypoxia adversely affects clinical radiation response of head and neck squamous cell carcinoma. 18F-fluoromisonidazole positron emission tomography ([F-18]FMISO-PET) offers a noninvasive means of assessing viable hypoxic tissue in tumor….
Background and objectives: Intraoperative frozen section analysis of surgical margins is widely used in head and neck cancer surgery. Their use in management of oral squamous cell carcimoma (SCC) and…
Background and objectives: MicroRNAs (miRNAs) are small non-coding double-stranded RNA with size of approximately 22 nucleotides, and those inhibit protein translation by binding the 3 f-untranslated region of target mRNAs….
Objectives: Since hematogeneous tumor cell dissemination is a key event in tumor progression we assessed the prognostic significance of disseminated tumor cells (DTCs) in BM and circulating tumor cells (CTCs)…
