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Drug Class:
Mechanism of Action
An aminoglycoside antibiotic that irreversibly binds to protein on bacterial ribosomes.
Therapeutic Effect: Interferes with protein synthesis of susceptible microorganisms, bacteriostatic.
Precautions and Contraindications
Hypersensitivity to kanamycin, other aminoglycosides (cross-sensitivity), or their components
Drug Class:
Indications and Dosages
Serious Reactions
! Continuous or repeated intermittent infusion may result in extreme somnolence and circulatory or respiratory depression.
! Too-rapid IV administration of ketamine may produce severe hypotension, respiratory depression, and irregular muscle movements.
! Prolonged respiratory depression: nondepolarizing muscle relaxants.
Dental Considerations
General:
• Warning: Ketamine should be administered by persons trained in the administration of general anesthesia. Patients must be continually monitored, and facilities for maintenance of a patent airway, ventilatory support, oxygen supplementation, and circulatory resuscitation must be immediately available. Strict aseptic technique must be followed in handling ketamine.
• Monitor for increased B/P and pulse rate; emergence reactions including hallucinations, delirium, dreamlike states, vivid imagery often accompanied by confusion, excitement, and irrational behavior.
• Responsible person must drive the patient home after recovery.
• Use safety measures: side rails, night light, and call bell within reach.
Drug Class:
Indications and Dosages
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