An internal derangement occurs when there is disturbance in the normal anatomic relationship between the disc and condyle of the Temporomandibular Joint (TMJ) that interferes with smooth movement of the joint and causes momentary catching, clicking, popping or locking. The objective of the study is to compare the efficacy of systemically administered Chondroitin Sulfate and Glucosamine Sulfate, Arthrocentesis alone and a combination therapy of Arthrocentesis followed by systemically administered Chondroitin Sulfate and Glucosamine Sulfate. In this study 75 patients diagnosed with Internal derangement were selected. They were divided into three groups (A–C). Group A underwent Arthrocentesis only. Second group were administered Chondroitin Sulfate and Glucosamine Sulfate. Third group underwent a combination therapy; Arthrocentesis was performed followed by systemically administering Chondroitin Sulfate and Glucosamine Sulfate for six months. The patients were followed up at intervals of 1, 3 and 6 weeks, then after 3 and 6 months, till 5 years. Assessment was based upon relief of symptoms and four criteria viz. Pain, Mouth opening, TMJ Sounds and Deviation/Deflection were chosen. This study shows that Arthrocentesis along with Chondroitin Sulfate and Glucosamine Sulfate is effective for internal derangement, however patients who are apprehensive about invasive procedures, Chondroitin Sulfate and Glucosamine Sulfate is an effective treatment modality.

Conflict of interest: None declared.