Introduction: Frey’s Syndrome (gustatory sweating) has been drescribed as a secretory alteration of the eccrine sweat glands located in the facial area due to an inappropriate response to cholinergic stimulus from the auriculotemporal nerve fibers. It is most frequently encountered as a complication of parotidectomy (12.5–62% by subjective methods, 22–98% using Minor’s starch–iodine test). Clinically it results in sweating and flushing of facial skin during salivation.

Materials and methods: 13 patients affected by Frey’s Syndrome after parotidectomy were selected. Stimulation of parotid secretion was performed using acid food. Subsequently, hyperhidrosis happened in the specific facial area and 1 centimeter sided squares were drawed on this region. Subcutaneous infiltration of 5 units of BotoxAlergan™ in each square centimeter was performed.

Results: After one week, patients were revalued by administration of the same acid food and decrease of sweating and flushing was showed comparing to previous situation. The 100% of the patients related improvement of their symptoms. Effects are temporary and infiltration should be repeated after 4–6 months.

Conclusion: Frey’s Syndrome is a common complication of parotidectomy and can be treated by subcutaneous botulinum toxin infiltration getting excellent results in the following 4–6 months after the administration.

Key words: Frey’s syndrome; parotidectomy