Effect of platelet-rich fibrin on osseointegration

Background and objectives: Platelet-rich fibrin (PRF) is as autogenous source of growth factors that stimulates and accelerates bone formation and soft tissue regeneration. Activated platelets in PRF secrete growth factors resulting cellular proliferation, collagen synthesis and osteoid production. The use of PRF in bone regeneration, both around dental implants and in periodontal treatments, has become particularly appealing. The aim of this study was to compare the stability of dental implants inserted with one-stage surgical protocol with or without PRF application.

Methods: 19 healthy patients with adequate alveolar bone, having at a minimum 2 adjacent missing teeth extracted at least 6 months ago were included in this study. After surgical preparation of implant sockets, preoperatively prepared PRF was placed randomly to one of the sockets (PRF+). Acellular plasma portion of PRF was used to wash the implant inserted into this socket while control implants (PRF−) were placed conventionally. Resonance frequency measurements were made by Osstell ISQ intraoperatively, on the post-operative first week, and the following first month. Statistical analysis of the data was performed.

Results: After operation, mean ISQ value of PRF+ group was 69.3 (+10.5) and 64.5 (+12.2) of PRF- group at the end of the first week. At the end of the fourth week mean ISQ for PRF+ group was 77.1 (+7.1) and 70.5 (+7.7) for PRF (−) group. PRF + group demonstrated significantly higher stability values during the study ( P < 0.05).

Conclusion: Results of this study demonstrated that PRF application increases implant stability during the early healing period. Simple application of this material seems to provide faster osseointegration.

Key words : platelet-rich fibrin; resonance frequency analysis; implant stability.

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Jan 21, 2018 | Posted by in Oral and Maxillofacial Surgery | Comments Off on Effect of platelet-rich fibrin on osseointegration

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