Objective: To analyze and evaluate the effect of multidisciplinary sequential treatment in dealing with oral mucosal malignant melanoma. In order to establish the routine of treatment with this disease.

Clinical data: From January 1994 to January 2008, the data of 106 patients undergoing treatments (cryosurgery, surgery, chemotherapy, and immunotherapy) for oral mucosal malignant melanoma were retrospected. The follow-up time was 2–14 years.

Results: There were 57 males and 49 females. The most common site was the palate. The second location was the gingiva, followed by the floor of mouth and tongue. The peak age of the disease in both sexes was 40–60 years. The rate of regional nodal and distant metastasis was about 70% and 40% respectively. The middle survival length of the patients was 4.5 years and the 5-year cumulative survival rate was 31%. The reason of death was distant metastases.

Conclusion: No single management strategy can be considered the standard of care. It is suggested that multidisciplinary sequential treatment should be the routine regimen of oral mucosal malignant melanoma.

Conflict of interest: None declared.