Several lesions occurring at the mandible require as the treatment of choice to minimize recurrence, an extensive resection with security margin. The rehabilitation of those patients promotes a great challenge for the surgeon, especially when the symphyseal area is involved. Traditionally, bone graft, harvested from a secondary donor site, with the use of microvascular reconstruction techniques or osseous free flaps are the procedures used to promote the reconstruction of the mandible, however, the weaknesses of bone graft still exist, and complications associated with the donor site are frequent. The distraction osteogenesis is a biological process of generating new bone by gradual traction of the divided bone segments. The technique of distraction osteogenesis was applied first in orthopaedic surgery for long-bone lengthening and was subsequently utilized in the treatment of cranio-facial microsomia and bone defect. The most significant advantage is that this technique can obviate any bone grafts and hence avoids donor site morbidity, also it allows the growth of soft tissue, minimizing dehiscence and bone exposure. This paper has the aim of presenting a case report of mandible reconstruction through the use of transport distraction osteogenesis and rehabilitation with osseointegrated implants and prosthetics in order to reconstruct a bone defect ranging from symphysis to temporomandibular joint in a patient who underwent mandibular resection due to odontogenic lesion, allowing the recovery of both function and aesthetics.