Introduction: In the oral cavity the most common malignant lesion is Squamous cell Carcinoma. Though the primary modality of treatment for patients with oral cavity cancer remains surgical resection, reconstruction and neck dissection many patients present with advanced disease and are thus treated using a multi-disciplinary approach. Patients with extracapsular spread of lymphatic metastasis and surgical margins that remain positive have been found to be at high risk for local-regional recurrence and death from disease, and are most often recommended to receive both post-operative radiation as well as systemic chemotherapy. Many lesions are curable where some advanced cases are treated with palliative intend.

Objectives: To conduct a clinico-pathologic review and outcome of oral squamous cell carcinoma with or without cervical lymph node metastasis in Bangladeshi patients.

Materials and methods: An observational study of 166 cases of oral squamous cell carcinoma with or without cervical lymph node metastasis was done from July 2005 to November 2012.

Results: A detailed data with analysis of 166 cases of oral squamous cell carcinoma in respect to age, sex, site prevalence, habit, clinical presentation, modalities of treatment and outcome will be presented.