Squamous cells carcinoma (SCC) is a malignant neoplasm drift of the squamous epithelium and it’s characteristic is multifactorial etiopathogenesis. Nowadays it’s known that Human Papillomavirus (HPV) is a risk factor, but the real impact is not really known. We develop a study to test the relationship between head and neck SCC (HNSCC) and HPV in our patients. Our study includes 156 patients treated in the Head and Neck Oncology Unit in Vall d’Hebron Hospital from January to December 2010. Epidemiological data and histological and image studies are collected, patients are classified depending on the outcome of HPV and comparative statistical studies are performed. Results demonstrate that HNSCC with positive HPV are more common in the tonsil an in the base of the tongue, affect both men and women, patients use to smoke less than patients with negative HPV and the tumour size is slightly smaller. It demonstrated an epidemiological link between HPV and HNSCC. Furthermore, we can affirm that the profile of patients with positive HPV HNSCC differs from that of typical profile of patients with HPV negative results.