The occurrence of hyperesthesia, flushing and sweating on cheek and pre-auricular area are signs and symptoms of Frey’s syndrome. This syndrome was firstly described in 1757 but only in 1923 Lucie Frey, a Frenchwoman medical, described this occurrence after neural damage. The incidence of this syndrome is rare and can be associated to direct or indirect damage of greater auricular nerve and/or auriculotemporal nerve; the spontaneous occurrence is extremely rare and can be associated with normality variation. Other rare case is the bilateral trifid mandibular condyle, usually this modification of the normal anatomy can be associated with fracture, but the association with embryological changes is rare. The aim of this case report is to show a rare case of spontaneous Frey’s syndrome associated with bilateral trifid mandibular condyle in a 17 years old male patient without history of facial trauma, the treatment of the signs and symptoms in this case with botulinum toxin type A.

Conflict of interest: None declared.