Methicillin-resistant Staphylococcus aureus (MRSA) was first recognized in 1961 and since then, it has caused countless infections and deaths worldwide. In the early 1980s, community acquired strains of MRSA emerged in addition to the previously recognized hospital acquired strains. The use or over-use of antibiotics has contributed to the development of, and selection of, these resistant strains. Fortunately, MRSA complication of oral and maxillofacial surgery procedures is not common. However, when MRSA does complicate a procedure, the effects can be devastating. A case will be herein presented of a Le Fort I osteotomy complicated by a fatal post-operative disseminated MRSA infection. The patient’s clinical course will be described as well as potential contributing factors to her death. A discussion of the use of antibiotics in orthognathic surgery will be included.

Conflict of interest: None declared.