Objective: Since it is necessary to make a prognosis and select treatment accordingly for oral squamous cell carcinoma, the evaluation of prognostic factors is important. We, therefore, investigated the relationships between clinical and histopathological factors of oral squamous cell carcinoma and the outcome.

Materials and methods: The subjects were patients with oral squamous cell carcinoma who underwent radical treatments. As evaluation factors, the T category, N category, clinical stage, and growth pattern were selected from clinical factors, and the degree of differentiation, mode of invasion, lymphatic invasion, vascular invasion, and perineural invasion from histopathological factors. Survival analysis was performed employing the Kaplan–Meier method, and the log-rank test was performed for univariate analysis between each factor and the outcome. Multivariate analysis was conducted using Cox’s proportional hazard model.

Results: Analysis involved 205 patients with a mean age of 64 years. Univariate analyses indicated that the T category, N category, stage, growth pattern, degree of differentiation, mode of invasion, lymphatic invasion, vascular invasion, and perineural invasion were all useful as prognostic factors. On multivariate analysis using these factors, the T category and mode of invasion were shown to be effective.

Conclusion: We evaluated the relationships of clinical and histopathological factors of oral squamous cell carcinoma with the outcome, and found the T category and mode of invasion to be the most useful prognostic factors.

Conflict of interest: None declared.