Background: Periodontal Disease Mechanisms and Wound Healing

Abstract

Periodontal diseases are one of the most common diseases in adults. Signs of mild periodontal inflammation are usually present in adults, and 10 to 60% of middle-aged adults have severe enough periodontal disease that requires treatment.

For diagnosis, it is helpful to understand the appearance of healthy periodontal tissues. This chapter begins with a description of periodontal health and reviews the contribution of microbes and immune system to the cellular changes that lead to the signs and symptoms of periodontal diseases. This is followed by reviews of periodontal wound healing and tooth development, and their influences on periodontal disease and treatment.

Learning Objectives

  • Recognize normal anatomy of healthy periodontal tissue.

  • Describe the contribution of microbes to the periodontal disease process.

  • Describe cellular and molecular events that lead to clinical signs and symptoms of periodontal disease.

  • Describe how periodontal tissue recovers from injury caused by bacteria or tissue trauma.

  • Describe how tooth development influences periodontal disease and treatment.

Case

A 25-year old healthy female dental student is seen for a periodontal exam as part of a clinical peer-to-peer exercise. See Fig. 1.1 for clinical presentation and Fig. 1.2 for radiographic presentation. She is currently satisfied with her dental condition, but had minor restorative treatment in the past and receives routine preventive dental care. She brushes and flosses regularly at least twice a day. These are the findings:

  • Soft tissue exam: No pathology other than the presence of small lingual tori.

  • Tooth condition: Small occlusal and interproximal amalgam restorations, and a slightly chipped maxillary incisor.

  • Periodontal measurements: Probing depths less than 5 mm, no bleeding on probing, no clinical attachment loss, furcation involvement, tooth mobility, and gingival recession. The gingiva is coral pink with patches of light pink on the maxilla, firmly attached to underlying hard tissue and stippled. The gingival margin follows the contours of the teeth in a scalloped fashion, and no plaque or calculus is present.

No Image Available!

Fig. 1.1 Clinical presentation for case.

No Image Available!

Fig. 1.2 Radiographic series for case.

Findings in the periodontal chart are as follows:

Maxilla facial

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

PD

323

323

323

323

323

312

222

212

212

312

212

212

313

334

BOP

CAL

000

000

000

000

000

000

000

000

000

000

000

000

000

000

GR

MGJ

767

767

768

635

678

989

983

379

989

976

556

667

656

656

Furc

PLQ

0

0

0

0

0

0

0

0

0

0

0

0

0

0

Maxilla lingual

PD

324

323

324

323

223

112

111

111

112

112

212

212

213

224

BOP

CAL

000

000

000

000

000

000

000

000

000

000

000

000

000

000

GR

Furc

Mobil

PLQ

0

0

0

0

0

0

0

0

0

0

0

0

0

0

Mandible lingual

32

31

30

29

28

27

26

25

24

23

22

21

20

19

18

17

PD

324

323

212

212

211

111

111

111

111

212

212

212

312

313

BOP

CAL

000

000

000

000

000

000

000

000

000

000

000

000

000

000

GR

MGJ

999

999

876

756

656

656

656

656

656

656

667

888

999

999

Furc

PLQ

Mandible facial

PD

324

223

212

212

211

112

212

212

213

212

212

313

323

323

BOP

CAL

000

000

000

000

000

000

000

000

000

000

000

000

000

000

GR

MGJ

635

535

535

535

647

656

644

457

757

656

646

656

655

433

Furc

Mobil

PLQ

0

0

0

0

0

0

0

0

0

0

0

0

0

0

Abbreviations: BOP, bleeding on probing (1), suppuration (2); CAL; clinical attachment level; Furc, furcation involvement (Glickman class); GR, gingival recession; MGJ, position of the mucogingival junction from margin; Mobil, tooth mobility (Miller grade); PD, probing depths; PLQ, plaque level (0 = none, 5 = heavy).

What can be learned from this case?

This dental student displays a good example of periodontal health. The description of the gingiva matches characteristics of periodontal health. Periodontal health is most commonly seen in young, healthy adults who receive frequent preventive care and practice effective oral hygiene.

Periodontal Health

Characteristics of Healthy versus Diseased Periodontal Tissues

As seen in the previous case, periodontal health means absence of signs and symptoms of periodontal disease. No signs of inflammation are present in any area of the gingiva (see Fig. 1.1), and all gingival landmarks are easily visible and in normal proportion to each other. Landmarks and areas of gingiva and mucosa are named as shown in Fig. 1.3.

No Image Available!

Fig. 1.3 (a) Oblique facial view of gingiva in patient seen in the preceding case with the different gingival landmarks and areas labeled. (b) Diagram of gingival landmarks. Healthy gingiva usually contains patches of stippling in the attached gingiva zone. (c) Diagram of a cross-section of healthy gingiva and periodontium attaching up to the cemento-enamel junction (CEJ). E = epithelium, CT = connective tissue. (d) Atraumatic extraction of a periodontally involved tooth reveals a depression in the interdental papilla called a “col,” which forms around wide interproximal contact points. Periodontal disease also produced the rough, pebbly epithelial surface that lined the extracted tooth. This is the sulcular epithelium that normally adapts tightly to the tooth surface inside the periodontal sulcus.

The case illustrates what periodontal health looks like, and clinical data matches many elements of periodontal health as shown in Table 1.2.

Most patients’ periodontal disease experience will fall somewhere on a spectrum of periodontal disease between perfect periodontal health and severe disease, matching all characteristics listed in Table 1.2. The challenge for a clinician is to decide whether a patient has sufficient signs and symptoms of the disease to warrant treatment.

Table 1.2 Findings in periodontal health vs. periodontal disease

Healthy

Diseased

Symptoms

None

May complain about:

Pain or soreness

Receding gums

Longer appearing teeth

Loose teeth

Red, swollen gum tissue

Bleeds when brushing/eating

Gingival appearance/

signs of periodontal disease

Color

Coral—pink

May have racial pigment

Erythematous (“red,” “beefy red”)

May have slightly purple/bluish hue

Firmness

Firm

Spongy, boggy, soft

Shape

Pointed interproximal papilla

Scalloped gingival margin

Often shows marginal groove

Blunted, swollen papilla

Loss of papilla

Flattened scallop pattern

Gingival swelling masks marginal groove

Adaptation

Flat (“knife-edged”) margin

Tightly adapted to teeth

Edematous/Swollen (“rolled”) margin

Easily deflectable

Other

Commonly has orange-peel texture (“stippling”)

Smooth and shiny gingival margin

May have fistula/sinus tracts

Margin may be friable

Clinical measurements/signs of periodontal disease

Probing depth

Low (1–3 mm usually)

High (>?4 mm)

Probing may be painful

Gingival bleeding

None or insignificant

Present (at least 10% of sites)

Clinical attachment

Intact (ideally 0 mm)

Sulcus feels firm and tight

Loss of attachment (>?0 mm, especially if interproximally)

Tooth mobility

None (or little for mandibular incisors; small teeth; petite individuals)

May be easily detectable

Recession

Ideally none

Common

Amount of gingiva

Greater than probing depths

May be less than probing depth

Furcation

Ideally none

Common

Plaque

None to low

Clearly detectable

Calculus

None to low

Clearly detectable

Radiographs

No bone loss

May have bone loss

Medical history

Typically healthy

Often has medical condition

Dental history

Usually has regular preventive care; frequent oral hygiene

Typically sporadic dental care and oral hygiene

Age

Typically younger

Typically older

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Dec 4, 2021 | Posted by in Periodontics | Comments Off on Background: Periodontal Disease Mechanisms and Wound Healing

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