Rationale: The TNM system for classification of Head and neck malignant tumours is a universally accepted, widely used, staging method which helps clinicians and researchers to choose from treatment options,…
Introduction: In the UK 5000–7000 head and neck cancer cases are diagnosed annually. Only 50 per cent are curable. The remaining terminal cases are managed by palliative care services in…
Background and objective: We have already demonstrated that post-operative concentration of salivary interleukin-6 (IL-6) may predict early locoregional recurrence in oral squamous cell carcinoma (OSCC) (Head & Neck; 2012). This…
Background and objectives: The most important prognostic factor for survival in tongue cancer is the presence of cervical lymph node metastases. Their presence determines the therapeutic strategy. 20–30% of stages…
Introduction: In the oral cavity the most common malignant lesion is Squamous cell Carcinoma. Though the primary modality of treatment for patients with oral cavity cancer remains surgical resection, reconstruction…
Background: Radiation therapy is often part of treatment of head and neck malignancies. After radiotherapy patients are at risk to develop osteoradionecrosis. The development of osteoradionecrosis is unpredictable and has…
Background and objectives: Patients with major salivary gland pathology may present with a suspected mass, diffuse glandular enlargement or symptoms of obstruction and inflammation. Various imaging modalities are available for…
Helicobacter pylori is a microaerophilic bacteria, gram-negative, spiral shaped and mobile which is believed to be one of the main factors responsible for gastritis, gastric ulcers and gastric cancer. H…
Introduction: Transoral robotic surgery (TORS) has been advocated as a means to de-intensify adjuvant therapy and to improve functional treatment outcomes in advanced stage oropharynx cancer. The purpose of this…
Background and objectives: Squamous cell carcinoma of the oral cavity is one of the ten most frequent cancers in developed countries. The purpose of this study was to identify predictors…
Objectives: The floor of mouth carcinoma (FOMC) displays some different characteristics compare to the other sites of oral squamous cell carcinoma (OSCC). This study aims to determine the characteristics and…
Background: Oral cancer, predominantly oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Despite advances in the treatment, the mortality rate of this disease has not…
Squamous cell carcinoma is one of the most common malignancies in head and neck region. Primary tumors, especially derived from undifferentiated cells, tend to have an aggressive phenotype, mainly characterized…
Background and objective: We have reported reciprocal switching in the keratin (K) subtype expression from K13 to K17 occurs during malignant transformation of the oral mucosa from normal and dysplastic…
Introduction: Squamous cell carcinoma of the oral cavity usually affects patients between the fifth and seventh decade of life but is increasingly seen in young patients under 40 years. Material…
The authors present the clinical case of a malignant paraganglioma of the parapharyngeal region: diagnosis, surgery and treatment with radiotherapy, MIBG-I131, chemotherapy and octreotid. 63 year old woman was referred…
Background and objectives: Fatty acid binding protein 4 (FABP4) is an intracellular lipid chaperone molecules that are expressed and involved in functions of adipocyte, macrophage, and dendritic cell. However, little…
Background and objectives: The aim of this study is to examine the effect of Image-guided stereotactic radiotherapy (IGSRT) in the treatment of advanced, recurrent lesions for head and neck carcinoma…
Tumor hypoxia adversely affects clinical radiation response of head and neck squamous cell carcinoma. 18F-fluoromisonidazole positron emission tomography ([F-18]FMISO-PET) offers a noninvasive means of assessing viable hypoxic tissue in tumor….
Background and objectives: MicroRNAs (miRNAs) are small non-coding double-stranded RNA with size of approximately 22 nucleotides, and those inhibit protein translation by binding the 3 f-untranslated region of target mRNAs….
