Thalassaemia and Other Blood Dyscrasias
Dentists will often treat children who suffer from blood dyscrasias (Box 48.1). It is essential to have a knowledge of the commonly encountered conditions, their oral manifestations and the precautions required for their dental management.
Anaemia is characterised by a reduction in the oxygen-carrying capacity of the blood. It is usually related to a decrease in the number of circulating red blood cells (RBCs) or to an abnormality in the Hb contained within the RBCs.
Anaemia is not a disease but rather a symptom that may result from:
- decreased production of RBCs (iron deficiency, pernicious anaemia, folate deficiency);
- blood loss or increased rate of destruction of circulating RBCs that may cause haemolytic anaemia.
Haemolytic anaemias may result from many other causes including:
- inherited abnormal haemoglobin (the haemoglobinopathies);
- inherited abnormal structure or function of the erythrocy/>