Prognostic factors in primary salivary gland mucoepidermoid carcinoma: an analysis of 376 cases in an Eastern Chinese population

Abstract

Mucoepidermoid carcinoma (MEC) is an infrequent malignant neoplasm that originates most commonly in the salivary glands. The present study aimed to provide new information on prognostic factors in patients with salivary gland MEC. A retrospective analysis of the medical records of patients diagnosed with primary salivary gland MEC between 2003 and 2010 was conducted. The incidence of MEC in the minor salivary glands (62.2%) was almost twice that in the major salivary glands (37.8%). The most frequently affected sites were the parotid gland and palate. Lymph node metastasis was reported more frequently in male than female patients ( P = 0.02), in high-grade than low/intermediate grade lesions ( P < 0.001), and in lesions involving the submandibular gland ( P < 0.001). The disease-free survival (DFS) at 5 years was 80.47%, with rates of 98.0%, 86.5%, and 38.5% for low-, intermediate-, and high-grade tumours, respectively. Among various clinicopathological factors, the only independent prognostic factor was histological grade ( P < 0.001). Primary tumour site and histological grade are two important factors affecting cervical lymph node metastasis. Histological grade is the only independent factor affecting survival beyond tumor lymph node metastasis (TNM) staging in salivary gland MEC. Further advances in therapy are needed to improve the outcomes for patients with high-grade lesions.

Salivary gland carcinomas are relatively rare, comprising less than 0.5% of all malignancies and less than 5% of head and neck malignancies worldwide. Among them, mucoepidermoid carcinoma (MEC) is the most frequently reported pathology, comprising approximately 30% of all salivary malignancies.

Primary MEC was first described by Stewart in 1945, and was initially known as benign mucoepidermoid tumour. This tumour displays a variety of biological behaviours, and while the high-grade variant is highly aggressive with a poor prognosis, the low-grade variant usually demonstrates a more benign nature with a satisfactory survival rate.

Several studies have described the relationships between the clinicopathological characteristics and clinical outcomes of salivary gland MEC. These characteristics include age, tumour size, histopathological grade, clinical stage, perineural and vascular involvement, and lymph node or distant metastases. However, since salivary gland MECs are relatively rare, most publications have been based on small sample sizes or have reported treatment protocols that have changed throughout the course of a long treatment period. Only a few studies have reported the results of multivariable analyses involving a large group of patients treated over a relatively short period of time. However, in these few studies, the samples have included both primary MEC and recurrent cases, which may have undermined the results.

The aims of the present study were to report on the clinical outcomes of primary salivary gland MEC and to identify prognostic factors for survival in a large group of Chinese patients.

Patients and methods

A retrospective study was conducted involving patients with MEC of the salivary gland who underwent primary tumour resection with curative intent. All patients were treated between January 2003 and December 2010. Inclusion criteria were: (1) primary MEC confirmed by pathology after surgery; and (2) no radiotherapy or chemotherapy before surgery. Three hundred and seventy-six patients were included in the study. The medical records were reviewed to evaluate clinical parameters, treatments, and clinical outcomes. The histological grade was reevaluated according to the revised World Health Organization classification of salivary gland tumours by two experienced pathologists. Major salivary gland tumours were staged according to the TNM classification of malignant tumours, and minor salivary gland tumours were staged according to their site of origin, in a similar fashion to squamous cell carcinomas.

Overall survival (OS) and disease-free survival (DFS) were determined by the Kaplan–Meier method, and the log-rank test was used to determine statistically significant differences in survival. For multivariate survival analysis, all variables were analyzed using the Cox proportional hazards regression model. A P -value less than 0.05 was defined as statistically significant (SPSS for Windows version 11.5; SPSS Inc., Chicago, IL, USA). This study was approved by the institutional review board.

Results

Patient characteristics

A total of 1263 patients with a diagnosis of salivary gland carcinoma were evaluated during the specified study period, of whom 376 were eligible for inclusion. Table 1 summarizes the demographic and clinicopathological data of the study population. The median age of the sample was 46.2 years (range 4–84 years). One hundred and seventy-five were male and 201 were female, showing a slight predominance in the female gender. However, in high-grade MEC cases, the male to female ratio was almost 3.5:1. The incidence of MEC in the minor salivary glands (234 cases, 62.2%) was almost twice that in the major salivary glands (142 cases; 37.8%). The most frequently affected site was the parotid gland, followed by the hard/soft palate and tongue–mouth floor region. Histologically, 145 patients (38.6%) had tumours classified as low-grade, 169 (44.9%) were intermediate-grade, and 62 (16.5%) were high-grade. According to the TNM classification, 258 patients were stage I/II, while 67 patients were stage III/IV. In addition, lymph node metastases were clinically present at initial staging in 41 patients (10.9%) and were confirmed after operation (pathological staging) in 52 (13.8%) patients.

Table 1
Demographic and baseline clinical characteristics of patients with primary mucoepidermoid carcinoma.
Characteristics
Evaluable patients, N 376
Ages, years, n (%)
<50 212 (56.4)
≥50 164 (43.6)
Median (range) 46.2 (4–84)
Gender, n (%)
Male 175 (46.5)
Female 201 (53.5)
Location, n (%)
Major salivary 142 (37.8)
Minor salivary 234 (62.2)
Grade, n (%)
Low 145 (38.6)
Intermediate 169 (44.9)
High 62 (16.5)
Nodal status, n (%)
Positive 52 (13.8)
Negative 324 (86.2)
Stage, n (%)
I + II 258 (68.6)
III + IV 67 (17.8)
Unknown 51 (13.6)
Only gold members can continue reading. Log In or Register to continue

Jan 19, 2018 | Posted by in Oral and Maxillofacial Surgery | Comments Off on Prognostic factors in primary salivary gland mucoepidermoid carcinoma: an analysis of 376 cases in an Eastern Chinese population
Premium Wordpress Themes by UFO Themes