Cyanoacrylate adhesives for fixation of xenografts S. Saska, É. T. Rossi, N. Conte Neto, S. F. Souza, M. A. C. Gabrielli, E. Hochuli-Vieira
Rev Cir Traumatol Buco-Maxilo-fac 2009: 9: 93–102
The aim of this study was to evaluate the ethyl-cyanoacrylate and butyl-2-cyanoacrylate adhesives for fixation of bovine bone grafts to the parietal bone of rabbits. Twenty adult rabbits ( Oryctolagus cuniculus ) received freeze-dried anorganic bovine bone grafts to the parietal skull region. Prior to the graft transplant, ostectomies were performed with a 6-mm trephine bur to create a recipient bed. The grafts were fixed with ethyl-cyanoacrylate in group I (GI) and with butyl-2-cyanoacrylate in group II (GII). The animals were sacrificed after 5, 15, 30, 60 and 120 days. The specimens were submitted to laboratory processing by haematoxylin and eosin staining. At 15 days, a slight inflammatory reaction was observed in both GI and GII. The presence of new bone formation around the graft was noted at 30 days in GI and at 60 days in GII. After 120 days, there was connective tissue found within the graft, new bone formation and remnant of adhesive. None of the grafts was completely replaced by newly formed bone in either GI or GII and remains of the grafted bone were still found. Both ethyl-cyanoacrylate and butyl-2-cyanoacrylate were biocompatible and both adhesives fixed the xenografts, providing adequate stability for new bone formation inside the graft and on the graft host bed interface. However, long-term evaluation is necessary to verify the complete degradation of the adhesives and substitution of the xenografts by newly formed bone.