Dentists are becoming increasingly aware of the importance of the detection and management of obstructive sleep apnea. The anatomic and neuromuscular risk factors in the pathogenesis of obstructive sleep apnea are reviewed with particular emphasis on oral findings. Mandibular repositioning appliances hold an important role in the treatment of this condition; however, knowledge of indications and contraindications for treatment, potential areas of oropharyngeal obstruction, appliance design, and treatment steps are vital to ensure maximum treatment success. A review of the steps involved in treatment and management with particular emphasis on collaborative care with physicians is presented.