Castleman’s disease (CD) is an uncommon lymphoproliferative disorder that was first described by Benjamin Castleman. In 1969 Flendrig published the first retrospective study of CD, in 1972 Keller identified histological features of the two subtypes of CD and classified them into into hyaline vascular (HV) and plasma cell (PC). In this abstract we pressent a case of large recurrent ameloblastoma that was treated with segmental mandibulectomy and immediately reconstruction with a free vascularized fibula flap, a super selective neck dissection performed to expose vessels for microvascular anastomosis for free fibula flap at the same time excision of the lymphnodes in the right level Ib and left Ia and IIa was performed due to their enlarged size on the preoperative CT-scan and were sent as frozen section for histopathologial analysis to role out the ameloblastic carcinoma. The final pathology confirmed the diagnosis of amleoblastoma and revealed that the involved lymphnodes were constant with CD.