Bioglasses are considered osteoconductive and osteoproductive biomaterials and some types also exhibit angiogenic, bacteriostatic and anti-inflammatory properties. Despite these facts, bioglasses have only a few commercial applications, mainly because they do not exhibit as good mechanical properties as titanium. This study evaluated the biological performance of titanium implants coated with a highly bioactive glass. The experimental study was performed in vivo and in vitro . The in vitro study was conducted by evaluating the adhesion and cell viability on titanium disks treated with highly bioactive glass. For the in vivo study, implants were installed in the mandibles of dogs Beagles. A group of implants presented a surface with double acid-etched and the other group had a surface with double acid-etched + highly bioactive glass. The results confirmed that coating pattern tested in this study is non cytotoxic and does not adversely affect the new bone formation on the implant interface, showing performance comparable to that of physically modified surface with double acid-etched. The results of this research do not demonstrated a significant increase in bone formation after the incorporation of bioactive glass on titanium surfaces, but indicates the possibility of modifying titanium surfaces in a predicable and promising way.