Central giant cell granuloma (CGCG) is benign uncommon intra-bony lesion accounting for less than 7% of all benign jaw lesions with female predilection. CGCG could be slowly progressive benign lesion or fast growing with aggressive behavior & mimicking malignant tumors. The management varies according to distinct of destruction from conservative treatment with intra-lesional infiltration of corticosteroid, calcitonin or interferon to the surgical en-block resection with micro vascular flap reconstruction or prosthetic obturator. The case history reported here is 22y old female presented with swelling in left posterior maxilla diagnosed as CGCG, subcutaneous 100 IU of calcitonin was given for 6 months then hemimaxillectomy with placement of surgical obturator,patient then refered to maxillofacial prosthodontist to construct final obturator.

Key words central giant cell granuloma; calcitonin injection; hemimaxillectomy; obturator