7: Ulcerative and Inflammatory Conditions

7 Ulcerative and Inflammatory Conditions

Ulcerative Conditions

Recurrent Aphthous Ulcers and Traumatic Ulcers

Most cases of recurrent aphthae are idiopathic; however, aphthous-like lesions are seen in Behçet disease, Crohn disease (often linear in the sulcus), hematinic deficiencies, some hypersensitivity reactions (to food, sodium lauryl sulfate found in toothpaste), cyclic neutropenia, and HIV infection. Complex aphthosis is often used to describe lesions associated with syndromes affecting the skin. Ulcers in children may be part of periodic fever, aphthosis, pharyngitis, and adenopathy (PFAPA) syndrome. Trauma and stress bring on episodes in susceptible individuals. Minor aphthous ulcers do not tend to be biopsied because of the typical history and presentation, whereas major ulcers are biopsied to rule out vesiculobullous disease. Chemotherapy-induced ulcerations are much larger, resolve predictably over 1 to 2 weeks, and are not aphthous ulcers.

Etiopathogenesis and Histopathologic Features

Most cases of recurrent aphthae have a strong family history of recurrent aphthae, and some HLA-A haplotypes have been identified. TNF-α plays an important role in etiopathogenesis.

Jan 12, 2015 | Posted by in Oral and Maxillofacial Pathology | Comments Off on 7: Ulcerative and Inflammatory Conditions
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