20: U

U

ulipristal

Do not confuse ulipristal with ursodiol.

Category and Schedule

Pregnancy Risk Category: X

Drug Class:

Contraceptive; progestin receptor modulator

Mechanism of Action

Postpones follicular rupture when administered prior to ovulation, thereby inhibiting or delaying ovulation. May also alter the normal endometrium, impairing implantation.

Therapeutic Effect: Reduces chance of unintended pregnancy.

Uses

Emergency contraception following unprotected intercourse or possible contraceptive failure

Pharmacokinetics

Rapidly absorbed after oral administration. 94% plasma protein bound. Hepatic metabolism via CYP3A4 to active and inactive metabolites. Half-life: 32 hr.

Indications and Dosages

Emergency Contraception

PO

Adults (females).

1 tablet (30 mg) as soon as possible, but within 120 hr (5 days) of unprotected intercourse or contraceptive failure.

Side Effects/Adverse Reactions

Frequent

Headache, abdominal pain, nausea

Occasional

Fatigue, dizziness

Precautions and Contraindications

Known or suspected pregnancy

Drug Interactions of Concern to Dentistry

• CYP3A4 inducers (e.g., carbamazepine, barbiturates, St. John’s wort): decreased effectiveness of ulipristal

Serious Reactions

Dental Considerations

General:

• Take precaution when seating and dismissing patient due to dizziness.

• Increased risk of nausea and vomiting (e.g., during sedation and impressions).

Teach Patient/Family to:

• Inform dentist when drug has been taken.

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Tags: Mosbys Dental Drug Reference 11e

Jan 5, 2015 | Posted by mrzezo in General Dentistry | Comments Off

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