Liquid nitrogen cryosurgery, boiling at −196 °C, has been shown to be an effective physicochemical treatment to decrease the recurrence rate of aggressive odontogenic lesions. Following enucleation and curettage of the lesion, the application of liquid nitrogen, generally by means of a spray but sometimes utilizing a probe, will devitalize bone to a depth of 1–2 mm beyond the visible edge of the bone. This devitalized bone retains it inorganic structure and forms a framework for new bone formation. If nerves are affected by the liquid nitrogen, they will generally recover and overall recurrence rates are decreased to 5–10%.