Antipsychotics

• Aripiprazole
• Chlorpromazine
• Haloperidol
• Olanzapine
• Quetiapine
• Risperidone
• ‐azine
• ‐apine
• ‐idone
• Mechanism of Action
  • Central dopamine receptor antagonist
• Clinical Implications
  • Continue drug perioperatively
  • If discontinued, have patient continue when surgery completed
  • Extrapyramidal side effects
    • Involuntary muscle contractions, tremors, and movement
    • More common with older agents (Haloperidol, chlorpromazine) and after recent medication change/increase
  • These medications can lead to neuroleptic malignant syndrome
    • Neuroleptic malignant syndrome management covered on page 275
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