Managing molars with severe molar-incisor hypomineralization: A cost-effectiveness analysis within German healthcare



Dentists have a range of options for managing molars with severe molar-incisor hypomineralization (MIH), each with different long-term implications. The cost-effectiveness of managing molars with severe MIH was assessed.


A mixed public-private-payer perspective within German healthcare was adopted. Individuals with one to four severely MIH-affected molars were followed over their lifetime. We compared: (1) removal of the tooth/teeth and orthodontic alignment of the second and third molars (Ex/Ortho); (2) restoration of the tooth using resin composite (Comp); (3) restoration using an indirect metal crown after temporizing it using a preformed metal crown (PMC/IR). The health outcome was tooth retention years. Transition probabilities were estimated based on the best available evidence. Cost calculations were based on German dental fee catalogues. Monte-Carlo microsimulations were performed for cost-effectiveness-analysis.


If extraction was performed at the optimal age (9.5/11 years for maxillary/mandibular molars), Ex/Ortho was most cost-effective (67 years, 446–938 Euro). Comp (51 years, 1911 Euro) and PMC/IR were dominated (50 years, 2033 Euro). This cost-effectiveness ratio was also determined when >1 molar was treated. If extraction was performed later, assuming no spontaneous alignment, Ex/Ortho was more costly than Comp, at least when only 1 molar was treated.


For molars with severe MIH, extraction at the optimal age and, if needed, orthodontic alignment can be cost-effective, especially when >1 molar is affected. For single molars where the chance of spontaneous alignment is low, Comp might also be considered. These findings apply to German healthcare and within the limitations of this study only.

Clinical significance: When deciding how to manage molars with severe MIH, both tooth retention, with lower costs but higher needs for re-treatments, and tooth removal, with possible need for orthodontic alignment, can be considered. Considering cost-effectiveness, the latter may be preferable, especially if the age of extraction is chosen correctly, or several molars are affected.


Qualitative, demarcated developmental hypomineralized defects of one or more permanent first molars, with or without signs of lesions on the incisors, are defined as molar-incisor hypomineralization (MIH) . Given the relatively high prevalence of 2–40% of MIH and the associated clinical symptoms (ranging from non-cavitated or cavitated structural defects to hypersensitivity or pain, or esthetic impairment), there is great need for effective management options for MIH .

A range of non-invasive, micro-invasive and invasive treatment options is theoretically available. The suitability of these, however, differs depending on the severity (mild to severe) and symptoms (with or without the association of hypersensitivity) of MIH. For severe cases (those with cavitated structural defects in the enamel) dentists can either (1) restore the defects directly (usually using resin composite), (2) restore them indirectly (for example using ceramic or metal restorations), or (3) remove the tooth, followed by spontaneous or orthodontic alignment of the adjacent teeth . Spontaneous alignment has been found in up to 82% and 63% of the adjacent teeth in the maxilla and mandible, respectively, under certain conditions and appropriate extraction timing .

Each of these options has a number of advantages and disadvantages: (1) Resin composite restorations do not require substantial tooth hard tissue removal, but have a significantly lower survival probability in MIH than non-MIH molars ; (2) Indirect restorations usually require additional preparation (substance loss), but have high survival probabilities. They are also more expensive than resin composites, and are unsuitable soon after eruption, but years later (when the final occlusion has settled). Therefore, MIH molars, which are planned to receive indirect restorations usually require temporization, for example with preformed metal crowns (PMC). (3) Removing the teeth is the most invasive option, but may achieve the best long-term prognosis: MIH molars have significantly increased treatment needs and after repeated re-interventions, extraction may be required. In this case, spontaneous or orthodontic alignment of adjacent teeth might not be feasible any longer, with replacement of the tooth (via bridges or implant-retained crown) being necessary.

The early treatment decision made for a molar with severe MIH has long-term consequences both clinically and economically: As described, certain treatments (such as resin composites) are initially far less costly than others (such as indirect restorations or removal and orthodontic alignment). They might, however, require more follow-up treatments, and earlier tooth loss, which increases long-term costs. The present study aimed to assess the cost-effectiveness of resin composite, indirect restorations, and tooth extraction plus (if needed) orthodontic treatment for severe MIH molars.


Setting, perspective, population, horizon

This study adopted a mixed public-private-payer perspective in the context of the German healthcare system. We modelled a population of initially 6-year old male individuals with one, two, to four permanent severe MIH-affected molars with a vital pulp. Molars were assumed to require restorative or surgical/orthodontic treatment, and were followed over the patient’s lifetime (TreeAge Pro 2013, TreeAge Software, Williamstown, MA, USA). Patient level costs were calculated, while effectiveness was calculated as mean value per molar (see below).


Based on a recent systematic review, the study team, which involved preventive and restorative clinicians, orthodontists, and pediatric dentists, appraised the available options. These were different directly placed restorations, such as resin composite, amalgam, compomer, glass ionomer cement restorations or preformed metal crowns; different indirectly placed restorations, such as metal, ceramic or composite inlays/onlays/crowns; extraction and orthodontic alignment if needed . It was decided to assess three different strategies, based on two key questions: (a) Which options are supported by the majority of data, where uncertainty in survival is low enough to yield estimates with certain robustness, and where new studies are unlikely to completely change that estimate?, and (b) Which options are representative for other options and could serve as indicator strategies (like resin composite, which − within the chosen setting − have similar costs to amalgam, compomer or preformed metal crowns), i.e. modelling further and similar options would have only limited information gain?

The three options we eventually chose were (1) the removal of the tooth and orthodontic alignment of the second and third molar (Ex/Ortho); (2) the restoration of the tooth using resin composite (Comp); (3) the restoration of the tooth using an indirect restoration, specifically, a non-precious metal crown, after temporizing the tooth using a preformed metal crown (PMC/IR). It should, however, be noted that the choice of these options was not decided using a formal consensus process, with other comparators being available and possibly also valid. Also note that removing affected teeth and leaving a gap was not considered an option within the German healthcare, while in other settings such strategy might be acceptable.

Model and assumptions

A model following patients and molars over their lifetime was constructed. Three main pathways were possible:

  • (1)

    Removal and alignment with or without active orthodontic treatment (Ex/Ortho). It was assumed that the patient had an Angle class I molar relationship without orthodontic treatment need. In our base-case scenario, it was assumed that the tooth was scheduled for extraction at the optimal age. Based on a recent systematic review , the assumed optimal age was 9.5 years for maxillary molars and 11 years for mandibular molars, with mean chances of spontaneous alignment being 83% and 63% (see Table 1 ). This age was increased to 14 years, assuming no spontaneous alignment at this age any longer, to model a worst case for this strategy. The MIH molar was temporized using a preformed metal crown (PMC), the chance of failure of PMCs was derived from a systematic review . After tooth removal, the sound second and third molar were assumed to be orthodontically aligned if needed, with space closure to be attempted from distal, which requires minimum anchorage. For this alignment, orthodontists can choose between a number of treatment modalities. A multi-bracket appliance, a transpalatal arch and/or a lingual arch and a reverse pull headgear (extraoral anchorage appliance) could be used for the mesialization of the second permanent molar (see below). Alternatively, the mesialization would be achieved by the use of a multi-bracket appliance, a transpalatal arch and/or a lingual arch and temporary anchorage devices (bone anchorage) as part of a mesialslider. These scenarios were assumed to be both representative for the reality within German healthcare; the first scenario for patients unwilling to pay any out of pocket costs, the second scenario for patients topping up their public health insurance treatment privately out of their own pockets (see below). Each scenario was modelled for missing 1, 2, 3 or 4 MIH-affected molars, with the position of the missing teeth (maxilla, mandible, or both) also being taken into consideration. Note that the second molar was assumed to be subject to caries increment after alignment into the first molar position. The caries increment was assumed to be constant over the patient’s lifetime, with 0.11 teeth being affected per year, as reported by a life course study from New Zealand . If carious lesions occurred, a resin composite restoration was assumed to be placed; this restoration was assumed to have a relatively limited surface extent, with the annual failure hazard being derived from a long-term cohort study from Denmark . Restored molars could experience restorative and non-restorative complications. Restorative complications led to repair of the restoration (possible once), replacement using resin composite (possible once), or replacement using non-precious metal crowns (in case repair or renewal were not possible any longer). The hazard of failure of repaired or renewed resin composites was derived from published studies in the field, as was the hazard of failure of crowns (see Table 1 ). In case of pulpal complications, root-canal treatment was assumed to be performed, followed by placement of a crown (as was expected after endodontic treatment). The hazard of failure of such therapy was derived from studies in the field ( Table 1 ). In follow-up health states, molars were again assumed to experience restorative complications (e.g. crown de-cementation, fracture or secondary caries, leading to re-cementation or renewal of crowns, or extractions) or endodontic complications (leading to non-surgical primary or secondary root-canal treatment or surgical re-treatment, i.e. apisectomy, or extraction). If molars extraction was required, tooth replacement was assumed to utilize implant-supported single crowns. Implants were assumed to experience restorative complications (requiring re-cementation or renewal of crowns) as well as biologic (e.g. peri-implantitis) or technical complications (like abutment or implant fracture); these were derived from systematic reviews. In case of implant removal, it was assumed that re-implantation would be attempted in 50% of the cases.

    Table 1
    Parameters used for effectiveness estimation.
    Health state Reference Transition probability per year Triangular distribution Allocation to Allocation probability
    Spontaneous alignment maxillary molar at age 9.5 years Eichenberger et al. 0.8;1.0;1.2 No orthodontic therapy
    Orthodontic therapy
    Spontaneous alignment mandibular molar at age 11 years Eichenberger et al. 0.7;1.0;1.3 No orthodontic therapy
    Orthodontic therapy
    Aligned second molar Broadbent et al. 0.011 0.1;1.0;3.0 Caries → composite 1.00
    Composite on MIH molar Elhennawy and Schwendicke 0.0436y −0.113 0.5;1.0;1.5 Repair
    Repaired composite Kanzow et al. RR = 3.4 relative to newly placed composite 0.9;1.0;1.6 Replaced composite
    Replaced composite Kanzow et al. RR = 1.4 relative to newly placed composite 0.7;1.0;1.7 Crown
    Preformed metal crown Elhennawy and Schwendicke 0.013 0.1;1.0;2.3 Crown or PMC
    Crown Burke and Lucarotti 0.076 0.7;1.0;1.7 Re-cementation
    RCT Ricucci et al. ;
    Schwendicke and Stolpe
    0.0232y −0.823 Non-surgical re-RCT
    Non-surgical re-RCT Ng et al. 0.059 0.3;1.0;2.0 Surgical re-RCT
    Surgical re-RCT Torabinejad et al. 0.080 0.5;1.0;2.0 Extraction 1.00
    Implant loss Jung et al. 0.032 0.5;1.0;1.7 Renewal
    Implant crown failure or loss Jung et al. 0.047 0.6;1.0;1.8 Renewal
  • (2)

    If MIH molars were retained and restored using resin composite (Comp), they followed the identical pathway as described for the second molar in pathway 1. However, the hazard of complications was adjusted to reflect the significantly increased risk of restorative or pulpal complications in MIH molars . In case of crown placement or root-canal treatment being required (assumed to lead to crown placement), the hazard of failure of MIH molars was no longer assumed to differ compared with non-MIH teeth.

  • (3)

    If MIH molars were retained and restored using indirect restorations, the assumption of temporization being required between age 6 and 18 was made, as indirect restorations would not be placed commonly in early childhood, but late adolescence. Temporization was assumed using a preformed metal crown (PMC/IR).

The constructed model is illustrated in Figure 1 . Model validation was performed internally by varying key parameters to check their impact on the results, by evaluating different model structures, and by performing sensitivity analyses.

Fig. 1
Transition diagram.

Health outcomes and measurement of effectiveness

The health outcome was tooth retention years; that is, the mean time a tooth was retained in a patient’s mouth. This was chosen as other possibly relevant measures, like experienced episodes of pain or provided number of re-treatments, could not be modelled due to scarcity of data. Similarly, quality of life data for MIH teeth were not available and could not be used to inform outcomes.

Transition probabilities to allow teeth to move from one health state to another (i.e. risks of complications and associated re-treatments) were estimated as described above, and are summarized in Table 1 . Note that for extracted MIH molars, the second and third molars were aligned to close the resulting gap. Tooth retention years were thus calculated for the first molar until removal, and for the second molar after alignment.

Resources and costs

Cost calculations were based on the German public and private dental fee catalogues, BEMA and GOZ , as described elsewhere . German dentists use fee items to claim for reimbursement for treatments. As most patients are members of the statutory insurance, for most procedures and patients items are drawn from the public catalogue BEMA. The catalogue is a detailed list of items, their definition and assigned fees, which can be charged. Procedures drawn from BEMA are usually fully (most conservative or surgical treatments) or partially (prosthetic treatments) covered and re-imbursed by the statutory insurance. For few treatments (composites, non-surgical re-root-canal treatment, implants, bone anchorage and mesialsliders), fees are derived from the private catalogue GOZ, which similarly lists items, with the difference being that more items are available, and that these can be charged at different factors. The most often used factor is 2.3, i.e. the basic fee is multiplied to reach the eventual fee, which is then paid privately by patients out of their own pocket (in case they have an additional private insurance, these costs might be reimbursed). We used the factor of 2.3 for our estimation of GOZ items. A small proportion (11%) of Germans are not members of the public insurance. For them, all items would be drawn from GOZ.

Within the analysis, the aim was to reflect the usual cost mix within German healthcare taking a mixed public-private payer’s perspective. Thus, costs for most procedures were estimated using BEMA, and if not-available there, GOZ was used. As for orthodontic treatment, costs vary significantly between a strict public and a public-private payer’s perspective. As mentioned above, both options are likely to occur within German healthcare. To reflect the resulting uncertainty, probabilistic sensitivity analyses (see below) were performed. Note that estimates do not fully apply to solely privately insured patients.

Given the lack of primary data, opportunity costs of patients’ time in treatment were not accounted for.

Discounting, currency and price date

Future costs were discounted at 3% per annum . Discounting accounts for time preference, i.e. opportunities lost or gained by spending money now instead of later, or experiencing health now instead of later. Discount rates were varied between 0 and 5% to explore the impact of higher or lower discounting. Costs were estimated in 2016 Euro.

Analytical methods

Monte-Carlo microsimulations were performed for analysis, with 1000 independent individuals (teeth) being followed over the average expected life-time of patients in annual cycles.

First, incremental-cost-effectiveness ratios (ICER) were used to express cost differences per gained or lost effectiveness when comparing the least costly with the most effective treatment option. Positive ICERs indicate additional costs per additional effectiveness, while negative ICERs indicate additional costs per effectiveness loss. Strategies which had higher effectiveness, but also higher costs (i.e. a positive ICER) compared with the least costly option were considered undominated, while strategies with additional costs but no additional effectiveness were considered dominated.

Second and to introduce parameter uncertainty, we sampled transition probabilities randomly from a triangular or uniform distribution of parameters ( Tables 1 and 2 ) .

Table 2
Cost-estimation per treatment complex. Costs were calculated by quantification of item-fees from public or private item catalogues. For further details see Appendix Tables S1-S4, Kanzow et al., 2016 , Schwendicke and Stolpe 2014 ; Schwendicke et al., 2013 .
Course of treatment Costs (Euro)
Replacement restoration using composite a 95.89
Preformed metal crown 96.78
Repair restoration b 69.42
Root canal treatment c 283.19
Full-metal crown 345.23
Orthodontic alignment (mean of public/private estimation, for details of ranges see Tabs. S4,5)
1 maxillary molar 1878.00
1 mandibular molar 2048.00
2 maxillary molars 2116.00
2 mandibular molars 2123.00
3 or 4 molars 3389.00
Re-cementation of a crown 54.29
Orthograde re-RCT 526.78
Apical surgery 154.63
Tooth/implant removal 67.41
Implant insertion 958.40

a Assumed 3 surfaces.

b Performed with composite, assumed 1 surface.

c Assumed 3 root canals per tooth.

Third, using estimates for costs (c, in Euro) and effectiveness (e, in years), the net benefit of each strategy combination was calculated using the formula

net benefit = λ × Δe − Δc,

with λ denoting the ceiling threshold of willingness to pay, i.e. the additional costs a decision maker is willing to bear for gaining an additional unit of effectiveness . If λ > Δc/Δe, an alternative intervention is considered more cost-effective than the comparator despite possibly being more costly . The net-benefit approach was used to calculate the probability of a strategy being acceptable regarding its cost-effectiveness for payers with different willingness-to-pay ceiling thresholds.

Lastly, univariate sensitivity analyses were performed to explore the impact of uncertainty and heterogeneity.

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Jun 17, 2018 | Posted by in General Dentistry | Comments Off on Managing molars with severe molar-incisor hypomineralization: A cost-effectiveness analysis within German healthcare
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