Clinico-pathological study on 551 cases of major salivary gland tumors H. Yamamoto, Y. Segawa, H. Shiratsuchi, et al.
Jpn J Head Neck Cancer 2008: 33: 548–551
Since salivary gland tumors have variable histological and biological characteristics, a correct histopathological diagnosis is important. The authors reviewed 551 cases of major salivary gland tumors that were surgically excised from 1983 to 2007. The 551 cases were comprised of 537 epithelial tumors (97.5%), 10 hematolymphoid tumors and 4 mesenchymal tumors. The epithelial tumors were located in the parotid gland (475 cases) and submandibular gland (62 cases). Malignancies accounted for 123 (22.9%) of the 537 epithelial tumors. The frequency of malignancies was much higher in the submandibular gland (45.2%) than in the parotid gland (20%). The common histological types among epithelial tumors were pleomorphic adenoma (285 cases; 53.1%), followed by Warthin’s tumor (19.4%), and those among malignant epithelial tumors were adenoid cystic carcinoma (25 cases), mucoepidermoid carcinoma (17 cases) and carcinoma ex-pleomorphic adenoma (15 cases). The risk of malignant transformation of pleomorphic adenomas was estimated as 5% (15 out of 300 cases). The histological subtypes of carcinoma ex-pleomorphic adenoma varied among the cases, and in 9 of 15 cases were salivary duct carcinoma, which is a high-risk carcinoma that requires careful attention.