7: G

G

Drug Class:

Anticonvulsant, analgesic

Indications and Dosages

image Postherpetic Neuralgia

PO

image Dosage in Renal Impairment

Dosage and frequency are modified on the basis of creatinine clearance:

Creatinine Clearance Dosage
60 ml/min or higher 400 mg q8h
30–59 ml/min 300 mg q12h
16–29 ml/min 300 mg daily
Less than 16 ml/min 300 mg every other day
Hemodialysis 200–300 mg after each 4-hr hemodialysis session

Serious Reactions

Dental Considerations

Drug Class:

Cholinesterase inhibitor

Serious Reactions

Dental Considerations

Drug Class:

Enzyme

Drug Class:

Antiviral, nucleoside analogue

Indications and Dosages

Serious Reactions

Dental Considerations

Drug Class:

Fluoroquinolone antiinfective

Indications and Dosages

image Topical Treatment of Bacterial Conjunctivitis Caused by Susceptible Strains of Bacteria

Ophthalmic

image Dosage in Renal Impairment

Creatinine Clearance Dosage
40 ml/min 400 mg/day
Less than 40 ml/min Initially, 400 mg/day, then 200 mg/day
Hemodialysis Initially, 400 mg/day, then 200 mg/day
Peritoneal dialysis Initially, 400 mg/day, then 200 mg/day

Serious Reactions

Dental Considerations

Drug Class:

Antineoplastic-miscellaneous; epidermal growth factor receptor inhibitor

Serious Reactions

Dental Considerations

Drug Class:

Antineoplastic-miscellaneous; nucleoside analogue

Indications and Dosages

Serious Reactions

Dental Considerations

General:

• Monitor vital signs at every appointment because of cardiovascular side effects.

• Consider semisupine chair position for patients with respiratory disease.

• If additional analgesia is required for dental pain, consider alternative analgesics in patients taking narcotics for acute or chronic pain.

• Examine for oral manifestation of opportunistic infection.

• Avoid products that affect platelet function, such as aspirin and NSAIDs.

• This drug may be used in the hospital or on an outpatient basis. Confirm the patient’s disease and treatment status.

• Chlorhexidine mouth rinse prior to and during chemotherapy may reduce severity of mucositis.

• Patient on chronic drug therapy may rarely present with symptoms of blood dyscrasias, which can include infection, bleeding, and poor healing. If dyscrasia is present, caution patient to prevent oral tissue trauma when using oral hygiene aids.

• Palliative medication may be required for management of oral side effects.

• Short appointments and a stress-reduction protocol may be required for anxious patients.

• Patients may be at risk of bleeding; check for oral signs.

• Oral infections should be eliminated and/or treated aggressively.

Drug Class:

Antihyperlipidemic

Drug Interactions of Concern to Dentistry

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Jan 5, 2015 | Posted by in General Dentistry | Comments Off on 7: G
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